http://alsfindingacure.org/images/homepage/slider/slide-1.jpg

Accelerating identification of cross-species suppressor genes and elucidating early pathophysiology in ALS

May 20, 2016

Research Summary

Generate animal models and human cell models that will more accurately parallel familial ALS (fALS).  The team will harness strengths of four powerful model systems (worms, flies, mice, human iPSCs) to develop a robust understanding of what goes awry in ALS neurons, while also identifying conserved, cross-species suppressor genes whose perturbation could stop ALS.

Investigators

  • Brown University
    • Justin Fallon
    • Anne Hart
    • Diane Lipscombe
    • Robert Reenan
    • Kristi Wharton
  • Massachusetts General Hospital
    • Brian Wainger
  • University of Massachusetts Medical School

Contact Us

A Program Of

Advisory Board

  • Leandro P. Rizzuto
  • Peter N. Foss
  • Merit  Cudkowicz, MD
  • Denis  Rizzuto
  • Stanley H. Appel, MD
  • Robert  Brown, D.Phil., MD
  • Tom  Gentile
  • Clive  Svendsen, PhD
  • Richard  Ellenbogen, MD
  • Randy  Fishman
  • Edward J. Rapp
  • Sudha  Maniam